<p> but there are still many patients find no reason, and the rising incidence of lung cancer, as well as younger and younger.Yang Jin Kee still remember the day three years ago, Corey admitted a 17-year-old female students in advanced lung cancer. This girls just admitted to Sichuan University, detection of gene mutation is not found, treatment costs would more than ten thousand yuan a month. Girls were disappointed, puzzled, while their parents go out to buy things, upstairs and jumped down. Yang Jin remember always remember her,hogan donna, this is the first patients he worked 13 years at Corrie encountered jumping. "If she could stay down,hogan bambino, technological advancements, might be able to find her target."Wyler House on the 8th floor,hogan donna, there is the country's largest cancer center clinical trials of drugs,hogan outlet roma, a lot of ongoing clinical trials of new drugs. Clinical trials of new drugs. Many people stereotype is the "mouse." In fact, clinical trials of drugs mainly refers to one, two and Phase III clinical trials of drugs,hogan scontate, low test the efficiency of the drug in the past, the high toxicity of the drug is now accurate treatment just turn, high effectiveness, very low toxicity. And it is based on genetic changes to the design of drugs,hogan saldi, experimental grasp relatively large, benefit more patients. At the same time, patients participate in clinical trials are not the rule of law the standard approach.</p>
<p> c-MET mutations account for 5% -10%. While the resistant patients,hogan uomo, this gene also play a role in fighting drugs. EGFR mutations in patients with 5% -20% of the drug because of c-MET gene amplification.Experimental and genetic studies of new drugsSome patients encountered EVIDENCE, first sentence and asked: "Is there new research I want to participate?." They are old lung cancer patient,outlet hogan, after 7-8 years of follow-up, found that the benefits of drug trials, hope to have new drugs to help They survive.Patients can detect mutations, although the majority.</p>
<p> because no way measured more with less. Wait until 2009, scientists including EVIDENCE team to re-establish a way to discover the sensitivity of different mutations in patients is not the same.At least 30% of the tumor cells EGFR mutations can be detected by conventional methods, but high sensitivity of the new method can detect 1% of tumor cell EGFR gene mutation has occurred, but we did not make the difference between the two linked.EVIDENCE very heart, he believes this approach can be inferred more with less relationship. With a specimen with both old and new methods to measuring the amount of gene mutation will appear, "such as new ways of measurement.</p>
<p> and we told them this drug stops,hogan online 2015, it will grow very slowly turned from very fast,hogan uomo, we must continue to use single this measure ,hogan prezzi, you can put the median survival of patients extended for six months or so. ""The study of tumors is endless, because too complex,hogan napoli, it will evolve." Zhang Xu Chao said.Cancer is a very tricky opponent, targeted drugs from second-generation to third generation now,hogan donna, the cancer drug offensive and defensive back and forth.EVIDENCE team with MIT, Harvard and other forces,hogan donna, working with the other driver gene in lung cancer fight --c-MET. They found that the gene "has suddenly magnify the role of" EVIDENCE is the leader of this global study, he is expected to announce the final results after two years. The preliminary data encouraging: in primary mutations.</p>
<p> some patient's tumor is not so ferocious, grow very slowly; others look at the patient's tumor grows very fast; some patients the body control very well, but grow new tumors somewhere.What are the reasons behind this in the end, he did not know. So EVIDENCE team used a mathematical model, the mathematical model of this phenomenon to calculus, draw three kinds of situation EGFR-resistant performance, given the different treatment strategies.EVIDENCE For example, such as EGFR mutations patient tumor grew a little, it seems obvious growing, but the drug can not stop, a stop will seriously deteriorate. "It was with the point of view is not the same clinical community. People say do not eat no effect to medication.</p>
<p> it is very sensitive, it shows large it mutated."EVIDENCE student Zhou Qing,scarpe uomo hogan, director of the physician in charge of relations do mutations lead content. Zhou Qing they found in the study, EGFR gene mutation greater the amount of patient medication, the better, the smaller the effect of mutations in the worse. They put the relationship between the amount of mutant named "mutation abundance,hogan interactive donna," abundance of people are more prone to low resistance,hogan estive, high abundance of people are less prone to drug resistance, drug effects can last a very long time.Although targeted drug and gene can bite close, but cancer cells is not a fool.On clinicians have found that some patients taking targeted drugs soon It does not hurt anymore, the spirit of improvement, to alleviate the symptoms. But about a year appeared resistant cancer cells know how to deal with targeted drugs,hogan, the patient has plunged into misery.EVIDENCE observed a very interesting phenomenon: taking the same kind of targeted drugs.</p>
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