<p> and lung cancer patients have a 70 percent to find targets - driven gene,hogan bimbi, the most common is the EGFR gene mutation and ALK fusion gene.Because these patients accounted for a large share of these 10 years we have gradually developed against these mutations targeted drugs,hogan sito ufficiale, only the terminally ill median overall survival from 10 months rose to 39-month magical effect.This is 10 years,hogan cheap, the team has been in the lead EVIDENCE draw Chinese human lung driven gene map. It is now possible for gene therapy targets mutations have been found close to 10, covering 85% of lung adenocarcinoma drive genes. For 54% of drivers gene, we have found drugs.Welch Allyn Building, 10th Floor, lung cancer Laboratory of Molecular Biology, the laboratory director is EVIDENCE student ZHANG Xu Chao.</p>
<p> especially in East Asia population mutation rate is particularly high, about 30% of all non-small cell lung cancer, while in the West the population is less than 10%, which is a very big distinction. "The study was published in 2005, caused a sensation in the industry."Resurrection" of targeted drugsEVIDENCE found that when patients have EGFR mutations,sneakers hogan, the use of such targeted drug Iressa progression-free survival may be extended to 9.5 months; but if the patient does not have the mutation, the use of drugs targeting the situation is worse than not. The study was published in 2009, Professor Shepherd former President of the International Association for the Study of lung cancer (IASLC) wrote that the study is especially "in the history of cancer research called one of the landmark studies,hogan scarpe uomo alte, the establishment of a new standard for the treatment of EGFR gene mutations in lung cancer."In Western countries intend to destroy Iressa when,hogan, in 2006, Wu Yilong and Professor Mo Shujin Chinese University of Hong Kong and seven clinical scientists led from Japan,hogan outlet italia, Thailand, launched "Iressa (gefitinib) Pan Asian research program. " They took an internationally recognized research mode.</p>
<p> EVIDENCE noticed the news was mostly domestic research on lung cancer research stay in cytology,scarpe hogan donna, as tutor of doctoral students EVIDENCE make all men stop the hands of the subject, into the activation of the EGFR gene mutation status of research.He recalled,hogan outlet 2015, also Iressa, clinical research in Japan a few years ago with American counterparts research data discrepancies, Japan has 10% of the effect, and the United States lower. "At that time no one dared to say this,hogan donna 2015, because if the drug has a different effect on different races, will be considered racial discrimination, has aroused great controversy in the medical profession."EVIDENCE team by analyzing the Guangdong Provincial People's Hospital 145 cases and Beijing, Shanghai, Guangzhou and other six cooperative unit activated a total of 506 cases of lung cancer patients with EGFR gene mutation status found that EGFR Chinese people is "special" driver gene."The epidermal growth factor receptor in China.</p>
<p> two groups of patients randomized,hogan online 2015, controlled efficacy to see the effect of Iressa and starch is not the same.In order to do this study, EVIDENCE brains. At that time a method of genetic testing in the world have not yet conclusive noisy,hogan rebel, directly to do genetic testing has been greatly restricted. They used an innovative nobody used method worldwide - with clinicopathological features to patient selection, and chose the two most representative features: do not smoke and pathology adenocarcinoma, there are these two characteristics The EGFR gene mutation is the most patient of people.EVIDENCE found that when patients have EGFR mutations, the use of such targeted drug Iressa progression-free survival may be extended to 9.5 months, significantly better than patients with chemotherapy alone; but if the patient does not have the mutation, the use of targeted drugs the situation is worse than not. Long-term follow-up analysis found that mutant EGFR-targeted treatment to patients, the median overall survival of 22 months.This study is referred to as the IPASS (Iressa Pan-Asia Study, Iressa Pan-Asia Study), published in 2009, more than a thousand cases of clinical trials have confirmed Iressa for patients with EGFR mutations effective rate of 70%.Why look before drugs ineffective,hogan outlet roma, because there is no specific group of people against. And let the drug effective, you must first check the EGFR gene mutations. "The results came out, it laid the pattern of lung cancer after research and development,rebel hogan, we must do first to lung cancer gene mutation,hogan prezzi, according to genetic mutations to determine treatment options." EVIDENCE of Chinese patients do genetic testing to get the same results, indicating that the conclusion is precise.This study shock lung cancer research academics.</p>
<p> Professor Shepherd former President of the International Association for the Study of lung cancer (IASLC) particular author said the study is "the history of cancer research called one of the landmark studies, the establishment of a new standard for the treatment of EGFR gene mutations in lung cancer" It was named Outstanding (Exceptional) Paper International F1000 biomedical literature evaluation system.The latest idea is to drive the gene for tumor therapy the tumor to figure out first, then design treatment programs. "If even the 'culprit' did not understand the blind medication,scarpe alte uomo tipo, blind treatment,outlet hogan marche, then the effect of these drugs may even not as a placebo."This study is of great practical significance.According to 2012 World Health Organization data, the global incidence of lung cancer 1.825 million cases per year, China had 653,000 cases, accounting for 35.8%. According to statistics, nearly 20 years may be due to social changes in lifestyle and environmental factors, the incidence of lung squamous cell ratio decreased, the incidence of lung cancer increased significantly.Pulmonary a provincial health department chief physician Yang Jin remember, for example, to the Guangdong Provincial People's Hospital, for example, admitted 1500 cases per year of new lung cancer patients with non-small cell lung cancer and small cell lung cancer accounts for 80% -85% and 15% -20%, respectively,hogan scarpe, of non- Small cell lung cancer is about 60 percent more lung cancer.</p>
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